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By: Prof. Philippe Gallusci and Dr Bernadette Rubio

Theorical part:
Studies in Arabidopsis and in many other plants including crops or trees, have demonstrated the relevance of epigenetic mechanisms in the control of development, response to stresses and their impact on agronomic traits and genome stability. Of course, epigenetic information is maintained during the life of a plant (somatic inheritance) and through vegetative propagation (clonal reproduction) during mitosis through the stem cells located in meristems. In contrast, the transmission of epigenetic information through generation is still a matter of debate. So far, there is no comprehensive view on an epigenetic inter/trans-generational memory, which may vary depending on the factors inducing the epigenetic variations, the type of variations as well as on reproduction mode (agamous or sexual reproduction). In line with these questions, we will discuss some of our recent data showing that the transcriptomic and epigenetic response to drought stress of tomato plants vary depending on the parental origin of the plants.
Practical part:
Using data generated in our laboratory, we will discuss the different bioinformatics steps that are necessary to obtain usable information to identify differentially methylated cytosines (DMCs) and regions (DMRs) using raw sequencing data generated after Whole Genome Bisulfite Sequencing.

May 18, 2022 02:00 PM in Paris

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